ImmunityBio (NASDAQ:IBRX) & Exelixis (NASDAQ:EXEL) Head-To-Head Analysis

Exelixis (NASDAQ:EXELGet Rating) and ImmunityBio (NASDAQ:IBRXGet Rating) are both medical companies, but which is the better investment? We will contrast the two businesses based on the strength of their profitability, valuation, analyst recommendations, dividends, risk, institutional ownership and earnings.

Earnings and Valuation

This table compares Exelixis and ImmunityBio’s gross revenue, earnings per share and valuation.

Gross Revenue Price/Sales Ratio Net Income Earnings Per Share Price/Earnings Ratio
Exelixis $1.43 billion 4.81 $231.06 million $0.92 23.39
ImmunityBio $930,000.00 1,921.32 -$346.79 million N/A N/A

Exelixis has higher revenue and earnings than ImmunityBio.

Volatility & Risk

Exelixis has a beta of 0.6, indicating that its share price is 40% less volatile than the S&P 500. Comparatively, ImmunityBio has a beta of 1.93, indicating that its share price is 93% more volatile than the S&P 500.


This table compares Exelixis and ImmunityBio’s net margins, return on equity and return on assets.

Net Margins Return on Equity Return on Assets
Exelixis 19.60% 13.77% 11.82%
ImmunityBio -45,735.72% N/A -112.52%

Analyst Ratings

This is a breakdown of current recommendations and price targets for Exelixis and ImmunityBio, as reported by MarketBeat.

Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Exelixis 0 1 7 0 2.88
ImmunityBio 0 0 1 0 3.00

Exelixis currently has a consensus target price of $31.13, indicating a potential upside of 44.63%. ImmunityBio has a consensus target price of $9.00, indicating a potential upside of 100.45%. Given ImmunityBio’s stronger consensus rating and higher possible upside, analysts plainly believe ImmunityBio is more favorable than Exelixis.

Institutional and Insider Ownership

82.7% of Exelixis shares are held by institutional investors. Comparatively, 8.7% of ImmunityBio shares are held by institutional investors. 2.9% of Exelixis shares are held by company insiders. Comparatively, 79.7% of ImmunityBio shares are held by company insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a company will outperform the market over the long term.


Exelixis beats ImmunityBio on 7 of the 12 factors compared between the two stocks.

About Exelixis

(Get Rating)

Exelixis, Inc., an oncology-focused biotechnology company, focuses on the discovery, development, and commercialization of new medicines to treat cancers in the United States. The company's products include CABOMETYX tablets for the treatment of patients with advanced renal cell carcinoma who received prior anti-angiogenic therapy; and COMETRIQ capsules for the treatment of patients with progressive and metastatic medullary thyroid cancer. Its CABOMETYX and COMETRIQ are derived from cabozantinib, an inhibitor of multiple tyrosine kinases, including MET, AXL, RET, and VEGF receptors. The company also offers COTELLIC, an inhibitor of MEK as a combination regimen to treat advanced melanoma; and MINNEBRO, an oral non-steroidal selective blocker of the mineralocorticoid receptor for the treatment of hypertension in Japan. In addition, it is developing XL092, an oral tyrosine kinase inhibitor that targets VEGF receptors, MET, AXL, MER, and other kinases implicated in growth and spread of cancer; XB002, an antibody-drug conjugate composed of human mAb against tissue factor (TF) for the treatment of advanced solid tumors; XL102, an orally bioavailable cyclin-dependent kinase 7 (CDK7) inhibitor for the treatment of advanced or metastatic solid tumors; and XB002 for the treatment of non-hodgkin's lymphoma. Exelixis, Inc. has research collaborations and license agreements with Ipsen Pharma SAS; Takeda Pharmaceutical Company Ltd.; F. Hoffmann-La Roche Ltd.; Redwood Bioscience, Inc.; R.P. Scherer Technologies, LLC; Catalent Pharma Solutions, Inc.; NBE Therapeutics AG; Aurigene Discovery Technologies Limited; Iconic Therapeutics, Inc.; Invenra, Inc.; StemSynergy Therapeutics, Inc.; Genentech, Inc.; Bristol-Myers Squibb Company; and Daiichi Sankyo Company, Limited. The company was formerly known as Exelixis Pharmaceuticals, Inc. and changed its name to Exelixis, Inc. in February 2000. Exelixis, Inc. was incorporated in 1994 and is headquartered in Alameda, California.

About ImmunityBio

(Get Rating)

ImmunityBio, Inc., a clinical-stage biotechnology company, develops therapies and vaccines to treat cancers and infectious diseases. It offers immunotherapy and cell therapy platforms, including antibody cytokine fusion proteins, synthetic immunomodulators, vaccine technologies, natural killer cells, and adaptive (T cell) immune systems. The company also develops therapeutic agents, which are in Phase II or III clinical trial for the treatment of liquid and solid tumors, including bladder, pancreatic, and lung cancers, as well as pathogens as SARS-CoV-2 and HIV. It has collaboration agreements with National Cancer Institute, National Institute of Deafness and Communication Disorders, and Amyris, Inc.; and license agreements with CytRx Corporation, EnGeneIC Pty Limited, GlobeImmune, Inc., and Infectious Disease Research Institute, Sanford Health, Shenzhen Beike Biotechnology Co. Ltd., Sorrento Therapeutics, Inc., and Viracta Therapeutics, Inc. The company was founded in 2014 and is based in San Diego, California.

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